- 专利标题： TGF Beta RECEPTOR ANTAGONISTS
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申请号： US16316714申请日： 2017-07-19
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公开(公告)号： US20190292179A1公开(公告)日： 2019-09-26
- 发明人: Robert M. Borzilleri , Peiyung Liu , Andrew J. Tebben , Upender Velaparthi , Hasibur Rahaman , Gopikishan Tonukunuru , Jayakumar Sankara Warrier
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 国际申请： PCT/US2017/042697 WO 20170719
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61K31/5383 ; A61K31/416 ; A61K31/5025 ; A61K39/395 ; C07D403/04 ; C07D487/04 ; C07D498/04
摘要：
The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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