公开(公告)号：US20190292179A1

公开(公告)日：2019-09-26

申请号：US16316714

申请日：2017-07-19

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Robert M. Borzilleri ,  Peiyung Liu ,  Andrew J. Tebben ,  Upender Velaparthi ,  Hasibur Rahaman ,  Gopikishan Tonukunuru ,  Jayakumar Sankara Warrier

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/5383 ,  A61K31/416 ,  A61K31/5025 ,  A61K39/395 ,  C07D403/04 ,  C07D487/04 ,  C07D498/04

摘要： The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.