- 专利标题： GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS AND STATIN RESPONSE, METHODS OF DETECTION AND USES THEREOF
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申请号： US16258961申请日： 2019-01-28
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公开(公告)号： US20190300958A1公开(公告)日： 2019-10-03
- 发明人: Lance Bare , James J. Devlin , Frits R. Rosendaal , Pieter H. Reitsma , Irene D. Bezemer
- 申请人： Celera Corporation , Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL)
- 主分类号： C12Q1/6883
- IPC分类号： C12Q1/6883 ; A61K31/40 ; A61K31/366 ; A61K31/22 ; A61K31/137 ; A61K45/06 ; A61K31/5377 ; A61K45/00 ; A61K31/4439 ; A61K31/37 ; A61K31/00 ; A61K31/4545 ; C07H21/04
摘要：
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment (particularly for reducing the risk of venous thrombosis). For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
公开/授权文献
- US3193523A Stabilization of polyesters with substituted carbodiimides 公开/授权日：1965-07-06
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