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121 条记录 (耗时 0.056 秒)

    Lung cancer markers and uses thereof
    2.
    发明授权
    Lung cancer markers and uses thereof 有权

    公开(公告)号：US11105806B2

    公开(公告)日：2021-08-31

    申请号：US16456363

    申请日：2019-06-28

    申请人： Celera Corporation

    发明人： Charles Birse ,  Steve Ruben ,  Marcia Lewis ,  Mehdi Mesri

    IPC分类号： C12Q1/6886 ,  G01N33/574

    摘要： Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

    Genetic polymorphisms associated with autoinflammatory diseases, methods of detection and uses thereof
    3.
    发明授权
    Genetic polymorphisms associated with autoinflammatory diseases, methods of detection and uses thereof 有权

    公开(公告)号：US11008618B2

    公开(公告)日：2021-05-18

    申请号：US15788125

    申请日：2017-10-19

    申请人： CELERA CORPORATION

    发明人： Steven Schrodi ,  Yonghong Li

    IPC分类号： C12Q1/6883 ,  C07K16/24

    摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with autoinflammatory diseases such as psoriasis. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

    LUNG CANCER MARKERS AND USES THEREOF
    5.
    发明申请
    LUNG CANCER MARKERS AND USES THEREOF 审中-公开

    公开(公告)号：US20200064347A1

    公开(公告)日：2020-02-27

    申请号：US16456363

    申请日：2019-06-28

    申请人： Celera Corporation

    发明人： Charles BIRSE ,  Steve RUBEN ,  Marcia LEWIS ,  Mehdi MESRI

    IPC分类号： G01N33/574 ,  C12Q1/6886

    摘要： Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

    GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF
    8.
    发明申请
    GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF 审中-公开

    公开(公告)号：US20190292598A1

    公开(公告)日：2019-09-26

    申请号：US15935506

    申请日：2018-03-26

    申请人： Celera Corporation

    发明人： Olga IAKOUBOVA ,  James J. DEVLIN

    IPC分类号： C12Q1/6883 ,  A61K31/70

    摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.