- 专利标题： USE OF VIRAL VECTORS IN THE TREATMENT OF RETINOBLASTOMA
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申请号： US16461680申请日： 2017-05-18
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公开(公告)号： US20190350992A1公开(公告)日： 2019-11-21
- 发明人: Manuel Maria CASCALLO PIQUERAS , Miriam BAZAN PEREGRINO , Angel MONTERO CARCABOSO , Guillermo Luis CHANTADA
- 申请人： VCN BIOSCIENCES SL , HOSPITAL SANT JOAN DE DEU
- 优先权： ESP201631473 20161117
- 国际申请： PCT/EP2017/061961 WO 20170518
- 主分类号： A61K35/761
- IPC分类号： A61K35/761 ; A61K38/47 ; C12N15/86 ; A61P35/04 ; A61K9/00
摘要：
A composition includes an oncolytic adenovirus. The composition can be used for treating retinoblastoma or removing or reducing metastases, secondary malignancies and or trilateral retinoblastoma associated with retinoblastoma. The oncolytic adenovirus has a sequence encoding a hyaluronidase enzyme inserted into its genome, and includes replication machinery specific for tumor cells.
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