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公开(公告)号：US20150342907A1
公开(公告)日：2015-12-03
申请号：US14420731
申请日：2013-01-21
IPC分类号： A61K31/137
CPC分类号： A61K31/137
摘要： The present invention relates to the field of pediatric or childhood tumor therapy. More specifically, the invention relates to the use of the allosteric activator of the calcium sensor receptor, cinacalcet, for the preparation of a pharmaceutical product for the treatment of neuroblastic tumors, particularly for the treatment of neuroblastomas, ganglioneuroblastomas and ganglioneuromas.
摘要翻译： 本发明涉及儿科或儿童肿瘤治疗领域。 更具体地，本发明涉及钙传感器受体（cinacalcet）的变构激活剂用于制备用于治疗成神经细胞瘤的药物产品，特别是用于治疗神经母细胞瘤，神经节细胞瘤和神经节细胞瘤的用途。
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公开(公告)号：US20200147027A1
公开(公告)日：2020-05-14
申请号：US16612806
申请日：2018-05-11
IPC分类号： A61K31/205 , A61K33/36 , A61K31/401 , A61K31/405 , A61K35/20 , A61P3/04
摘要： The present invention provides a betaine compound for use in the prevention of obesity, excessive fat accumulation and/or metabolic disorders associated with either of the foregoing in a subject, wherein the prevention comprises administering the betaine compound directly to the subject during infancy or, alternatively, to the subject's mother during breast-feeding. Also provided are compositions comprising an effective amount of betaine compound together with one or more pharmaceutically or edible acceptable excipients and/or carriers for this use.
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公开(公告)号：US09561190B2
公开(公告)日：2017-02-07
申请号：US14389330
申请日：2013-03-27
IPC分类号： A61K9/70 , A61K9/00 , D01D5/00 , D01D10/00 , D01F11/08 , A61K47/34 , A61K31/4745 , A61M35/00 , D04H1/728 , D04H3/016 , D04H5/02
CPC分类号： A61K9/7007 , A61K9/0024 , A61K9/70 , A61K31/4745 , A61K47/34 , A61M35/00 , D01D5/0007 , D01D5/003 , D01D10/00 , D01F11/08 , D04H1/728 , D04H3/016 , D04H5/02 , D10B2331/041 , D10B2509/00
摘要： The invention defines a nonwoven membrane for the controlled and sustained release of a therapeutic or cosmetic active agent in the area of the body to be treated. This nonwoven membrane comprises one single type of biocompatible electrospun nanofibers and microparticles of at least one therapeutic or cosmetic active agent which are entangled between the nanofibers, the active agent having a low water solubility.
摘要翻译： 本发明限定了用于在待治疗的身体区域中治疗或美容活性剂的受控和持续释放的非织造膜。 该非织造膜包含一种单一类型的生物相容性电纺丝纳米纤维和至少一种治疗或美容活性剂的微粒，其在纳米纤维之间缠结，活性剂具有低水溶性。
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公开(公告)号：US20150072008A1
公开(公告)日：2015-03-12
申请号：US14389330
申请日：2013-03-27
IPC分类号： A61K9/70 , A61K31/4745 , D01D5/00 , A61M35/00
CPC分类号： A61K9/7007 , A61K9/0024 , A61K9/70 , A61K31/4745 , A61K47/34 , A61M35/00 , D01D5/0007 , D01D5/003 , D01D10/00 , D01F11/08 , D04H1/728 , D04H3/016 , D04H5/02 , D10B2331/041 , D10B2509/00
摘要： The invention defines a nonwoven membrane for the controlled and sustained release of a therapeutic or cosmetic active agent in the area of the body to be treated. This nonwoven membrane comprises one single type of biocompatible electrospun nanofibers and microparticles of at least one therapeutic or cosmetic active agent which are entangled between the nanofibers, the active agent having a low water solubility.
摘要翻译： 本发明限定了用于在待治疗的身体区域中治疗或美容活性剂的受控和持续释放的非织造膜。 该非织造膜包含一种单一类型的生物相容性电纺丝纳米纤维和至少一种治疗或美容活性剂的微粒，其在纳米纤维之间缠结，活性剂具有低水溶性。
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公开(公告)号：US20220304666A1
公开(公告)日：2022-09-29
申请号：US17619909
申请日：2020-05-26
申请人： FUNDACIÓ CELLEX , HOSPITAL SANT JOAN DE DEU , INSTITUT QUÍMIC DE SARRIÀ CETS FUNDACIÓ PRIVADA , HOSPITAL CLÍNIC DE BARCELONA , INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS) , UNIVERSITAT DE BARCELONA
发明人： Eduard GRATACOS SOLSONA , Elisenda EIXARCH ROCA , German FEBAS BOSOMBA , Salvador BORRÓS GÓMEZ , Talita MICHELETTI HELFER
IPC分类号： A61B17/00
摘要： Patch (1) for sealing an amniotic membrane, wherein the patch (1) comprises a support (11) and an adhesive (12) that is activated in presence of amniotic liquid or a wet environment. Device for placing said patch (1) comprising a cannula (2) for inserting said patch (1) in a rolled-up position, said cannula (2) being provided with a handle (3); and a dipstick (4) provided with a pusher (5), said dipstick (4) being inserted inside the cannula (2) in the use position. The patch adheres efficiently on the amniotic membrane, adapts to the elastic properties of this membrane, and by attaching only to the amnion it does not interfere with the natural sliding movements of one membrane against each other, together with the device to ensure that the patch is placed in the proper position without damaging the membrane.
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公开(公告)号：US20210290639A1
公开(公告)日：2021-09-23
申请号：US17265198
申请日：2019-08-01
IPC分类号： A61K31/585 , A61K9/00 , A61K31/4439 , A61K31/155 , A61K9/28 , A61K9/20
摘要： Immediate release formulation of a triple combination of active pharmaceutical ingredients useful in the treatment of polycystic ovarysyndrome It relates to an immediate release formulation for oral administration, comprising; a) a combination of three active pharmaceutical ingredients which are spironolactone; pioglitazone or a salt thereof; and metformin or a salt thereof; and b) solid polyethylene glycol having an average molecular weight from 3350 to 8000 g/mol; wherein: each of the active pharmaceutical ingredients are present in a therapeutically effective amount; and the polyethylene glycol is present in an amount such that decreases the dissolution profiles in vitro of each one of the active pharmaceutical ingredients without modifying the disintegration time of the formulation compared with the dissolution profiles of each one of the active pharmaceutical ingredients of a formulation having the same composition but without the solid polyethylene glycol, as well as, to its preparation process.
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公开(公告)号：US20240285784A1
公开(公告)日：2024-08-29
申请号：US18028515
申请日：2021-09-27
申请人： FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) , UNIVERSITAT DE BARCELONA , HOSPITAL SANT JOAN DE DEU
发明人： Macarena SANCHEZ NAVARRO , Meritxell TEIXIDÓ TURÁ , Nagore GENÉ OLACIREGUI , Ernest GIRALT LLEDÓ , Angel MONTERO CARCABOSO
CPC分类号： A61K47/64 , A61K47/542 , A61K47/545 , A61P35/00
摘要： Peptidic conjugates of SN38, process for their preparation, pharmaceutical compositions comprising them, and their therapeutical indications as anticancer drugs.
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公开(公告)号：US20190350992A1
公开(公告)日：2019-11-21
申请号：US16461680
申请日：2017-05-18
发明人： Manuel Maria CASCALLO PIQUERAS , Miriam BAZAN PEREGRINO , Angel MONTERO CARCABOSO , Guillermo Luis CHANTADA
IPC分类号： A61K35/761 , A61K38/47 , C12N15/86 , A61P35/04 , A61K9/00
摘要： A composition includes an oncolytic adenovirus. The composition can be used for treating retinoblastoma or removing or reducing metastases, secondary malignancies and or trilateral retinoblastoma associated with retinoblastoma. The oncolytic adenovirus has a sequence encoding a hyaluronidase enzyme inserted into its genome, and includes replication machinery specific for tumor cells.
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公开(公告)号：US20190060328A1
公开(公告)日：2019-02-28
申请号：US15771317
申请日：2016-10-27
发明人： Lourdes IBAÑEZ , Francis DE ZEGHER
IPC分类号： A61K31/585 , A61K31/4439 , A61K31/155 , A61P15/08
摘要： The present invention relates to a method and composition for use in treating a condition that benefits from the reduction of hepatic and/or visceral fat, such as polycystic ovary syndrome in adolescent girls or women of childbearing age, involving the use of spironolactone, pioglitazone and metformin.
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公开(公告)号：US20180207111A1
公开(公告)日：2018-07-26
申请号：US15745789
申请日：2015-07-22
IPC分类号： A61K31/137 , A61K45/06 , A61P35/00 , C12Q1/6886 , G01N33/574
CPC分类号： A61K31/137 , A61K45/06 , A61P35/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57407 , G01N33/57484 , G01N2800/52 , A61K2300/00
摘要： Methods for increasing susceptibility of cancer cells to immunotherapeutic agents and methods for assessing the effectiveness of a cancer treatment.
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