Robotic systems and methods for the automatic guidance of medical catheters into anatomical structures during various medical procedures are disclosed. A motor controlled insertion mechanism and a motor controlled rotation mechanism are configured to combine catheter insertion and rotation such as to twist the catheter while advancing into the anatomical structure. A navigation-system determines the position in the anatomical structure of a tracking-sensor disposed on the tip of the catheter. The motion of the catheter is controlled via the motors A controller controls, via the motors, the movement of the catheter into the anatomical structure function of the position of the tracking sensor. The methods, systems and devices described herein significantly decrease X-ray exposure to both patient and doctor, minimize friction between the catheter and robotic components, reduce the size of robotic systems, reduce production costs, and reduce the duration of clinical procedures.