发明申请
- 专利标题: NOVEL T-CELL RECEPTOR
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申请号: US16483876申请日: 2018-02-05
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公开(公告)号: US20200010804A1公开(公告)日: 2020-01-09
- 发明人: Tetsuya Nakatsura , Toshiaki Yoshikawa , Yasushi Uemura , Kyoko Fukuda , Shin Kaneko , Atsutaka Minagawa , Yoshiaki Kassai , Atsushi Matsuda
- 申请人: National Cancer Center Japan , Kyoto University , Takeda Pharmaceutical Company Limited
- 优先权: JP2017-019883 20170206
- 国际申请: PCT/JP2018/003799 WO 20180205
- 主分类号: C12N5/0783
- IPC分类号: C12N5/0783 ; C07K14/725 ; C12N15/86 ; A61P35/00 ; A61K35/17
摘要:
Provided is a T cell receptor containing, as α chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 1 to 3, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 4 to 6, as β chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 7 to 9, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 10 to 12, and capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 27 or a complex of the peptide and HLA-A24. A T cell receptor containing, as an α chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 13 to 15, as β chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 16 to 18, and capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 28 or a complex of the peptide and HLA-A02.
公开/授权文献
- US11603519B2 T-cell receptor 公开/授权日:2023-03-14
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