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    NOVEL T-CELL RECEPTOR
    3.
    发明申请
    NOVEL T-CELL RECEPTOR 审中-公开

    公开(公告)号：US20200010804A1

    公开(公告)日：2020-01-09

    申请号：US16483876

    申请日：2018-02-05

    申请人： National Cancer Center Japan ,  Kyoto University ,  Takeda Pharmaceutical Company Limited

    发明人： Tetsuya Nakatsura ,  Toshiaki Yoshikawa ,  Yasushi Uemura ,  Kyoko Fukuda ,  Shin Kaneko ,  Atsutaka Minagawa ,  Yoshiaki Kassai ,  Atsushi Matsuda

    IPC分类号： C12N5/0783 ,  C07K14/725 ,  C12N15/86 ,  A61P35/00 ,  A61K35/17

    摘要： Provided is a T cell receptor containing, as α chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 1 to 3, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 4 to 6, as β chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 7 to 9, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 10 to 12, and capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 27 or a complex of the peptide and HLA-A24. A T cell receptor containing, as an α chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 13 to 15, as β chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 16 to 18, and capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 28 or a complex of the peptide and HLA-A02.

    HEMATOPOIETIC PROGENITOR CELL MARKER
    6.
    发明申请
    HEMATOPOIETIC PROGENITOR CELL MARKER 有权

    公开(公告)号：US20210102167A1

    公开(公告)日：2021-04-08

    申请号：US16607967

    申请日：2018-04-25

    申请人： Kyoto University ,  Takeda Pharmaceutical Company Limited

    发明人： Shin Kaneko ,  Shoichi Iriguchi ,  Yuta Mishima ,  Yoshiaki Kassai ,  Akira Hayashi ,  Suguru Arima

    IPC分类号： C12N5/0783 ,  G01N33/569

    摘要： Provided is a method for producing a CD4/CD8 double positive cell, including the following steps: step 1: separating, from a cell population containing a hematopoietic progenitor cell, a cell expressing one or more kinds of molecules selected from the first group consisting of CD24, CD62L, CD90, CD143, CD263, Notch3, CD32, CD39, CD49a, CD164, CD317, CD200, CD218a, CD7, CD144, CD56, CD226, CD262 and CD325, and/or a cell not expressing one or more kinds of molecules selected from the second group consisting of CD49f, CD51, CD102, CD42b, CD61, CD62P, CD69, CD102 and CD156c, and step 2: differentiating the cell separated in step 1 into a CD4/CD8 double positive cell.