The present disclosure relates to nicotinamide adenine dinucleotide (oxidized form) preparations and the use of hygroscopic components to prevent decomposition of the nicotinamide adenine dinucleotide (oxidized form). These compounds can then be prepared and administered nasally, sublingually, vaginally, rectally and topically to the skin to serve as nutritional supplements, medical foods or drugs. These compounds can also be used in the manufacture of nicotinamide adenine dinucleotide (oxidized form) preparations in transdermal patches, and inhalation preparations.