公开(公告)号：US20240424090A1

公开(公告)日：2024-12-26

申请号：US18287669

申请日：2022-04-20

Applicant: INSTITUT CURIE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  STIMUNITY

Inventor： NICOLAS MANEL ,  BAKHOS JNEID

IPC: A61K39/395 ,  A61K9/51 ,  A61K31/7084 ,  A61K39/00 ,  A61P35/00

Abstract: The present invention relates to a pharmaceutical combination comprising i) cyclic dinucleotides packaged into a virus-like particle (VLP) and ii) an anti-CTLA-4 antibody or a fragment thereof binding a CTLA-4 antigen, and to uses thereof, in particular for the treatment of cancer or of a STING-mediated disease or disorder.

公开(公告)号：US20240423927A1

公开(公告)日：2024-12-26

申请号：US18287664

申请日：2022-04-20

Applicant: INSTITUT CURIE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  STIMUNITY

Inventor： NICOLAS MANEL ,  BAKHOS JNEID

IPC: A61K9/51 ,  A61K31/506 ,  A61K31/7084 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28 ,  C12N15/86

Abstract: The present invention relates to a pharmaceutical combination comprising i) a vector comprising a stimulator of interferon genes (STING) activator and ii) an anti-regulatory T cells (Tregs) agent, and to uses thereof, in particular for the treatment of cancer or of a STING-mediated disease or disorder.

公开(公告)号：US12150461B2

公开(公告)日：2024-11-26

申请号：US18289200

申请日：2022-01-19

Applicant: Sovida Solutions Ltd.

Inventor： Hanns-Eberhard Erle ,  Johannes Holzmeister ,  Anne Abriat

IPC: A61P17/00 ,  A23J3/16 ,  A23J3/18 ,  A23J3/20 ,  A23J3/22 ,  A23J3/26 ,  A23L5/10 ,  A23L5/46 ,  A61K9/127 ,  A61K31/7084

Abstract: Disclosed herein are compositions that include nicotinamide adenine dinucleotide (NAD), precursors thereof, derivatives thereof, or mixtures thereof encapsulated in a liposome, wherein the compositions exhibit enhanced chemical, physical, and/or microbial storage stability at a variety of storage temperatures. In certain embodiments, the compositions are stable and have positive permeability and senescence results. Also disclosed herein are methods for preparing such compositions and methods of using such compositions.

公开(公告)号：US20240335464A1

公开(公告)日：2024-10-10

申请号：US18253425

申请日：2021-11-18

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Michael H. SHAW ,  Yosuke SATO

IPC: A61K31/7084 ,  A61K39/00 ,  A61K39/395 ,  A61N5/10 ,  A61P35/00

CPC classification number: A61K31/7084 ,  A61K39/3955 ,  A61N5/10 ,  A61P35/00 ,  A61K2039/545

Abstract: The present disclosure provides methods, pharmaceutical compositions, and kits for treating cancer in patients in need thereof. The methods comprise administering to a patient in need a STING (stimulator of interferon genes) agonist, such as Compound No. 14 as defined in the description, or a pharmaceutically acceptable salt thereof, in combination with one or more checkpoint inhibitors and radiation. Also provided are medicaments for use in treating cancer.

公开(公告)号：US20240293550A1

公开(公告)日：2024-09-05

申请号：US18396613

申请日：2023-12-26

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Matthew Hassler ,  Julia Alterman ,  Bruno Miguel da Cruz Godinho

IPC: A61K47/26 ,  A61K31/7084 ,  A61K47/54 ,  A61K47/55 ,  C07H3/08 ,  C07H21/04 ,  C07H99/00 ,  C12N15/11 ,  C12N15/113

CPC classification number: A61K47/26 ,  A61K31/7084 ,  A61K47/549 ,  A61K47/55 ,  A61K47/551 ,  C07H3/08 ,  C07H21/04 ,  C07H99/00 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2310/52

Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.

公开(公告)号：US20240245736A1

公开(公告)日：2024-07-25

申请号：US18375171

申请日：2023-09-29

Applicant: LIFE WELL LIVED, LLC

Inventor： Roxanne SMITH ,  Jonathan RINKER ,  Kent HOWARD

IPC: A61K35/747 ,  A61K9/00 ,  A61K31/122 ,  A61K31/355 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/7084 ,  A61K31/714 ,  A61K33/30 ,  A61K35/00 ,  A61K35/745 ,  A61K45/06

CPC classification number: A61K35/747 ,  A61K9/0053 ,  A61K31/122 ,  A61K31/355 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/7084 ,  A61K31/714 ,  A61K33/30 ,  A61K35/745 ,  A61K45/06 ,  A61K2035/11

Abstract: Disclosed are compositions and methods for reducing blood alcohol content following alcohol consumption. The inventive compositions and methods rapidly reduce blood alcohol content and alleviate symptoms of intoxication in a subject having an elevated blood alcohol content due to alcohol consumption.

公开(公告)号：US20240173347A1

公开(公告)日：2024-05-30

申请号：US18522970

申请日：2023-11-29

Applicant: ACCURI, LLC

Inventor： Boying DUN ,  Jin-Xiong SHE

IPC: A61K31/7084 ,  A61K31/198 ,  A61K31/455 ,  A61K31/7004 ,  A61K31/7012 ,  A61K31/706 ,  A61P43/00

CPC classification number: A61K31/7084 ,  A61K31/198 ,  A61K31/455 ,  A61K31/7004 ,  A61K31/7012 ,  A61K31/706 ,  A61P43/00

Abstract: Provided herein are compositions and methods of use thereof for efficiently raising NAD levels in a subject in need thereof, and improving the body's functions associated with low NAD levels. The composition comprises NAD precursors and additional components that elevate NAD levels and improve mitochondrial and cellular functions. The additional components include NAD+, NADH, D-ribose and creatine monohydrate, nicotinamide and/or nicotinic acid (NA) and may be added to the formulation to further enhance the composition's efficacy.

公开(公告)号：US20240115594A1

公开(公告)日：2024-04-11

申请号：US18352220

申请日：2023-07-13

Applicant: MAIA Biotechnology, Inc.

Inventor： Sergei Gryaznov ,  Jerry Shay

IPC: A61K31/7084 ,  A61P35/00

CPC classification number: A61K31/7084 ,  A61P35/00

Abstract: Disclosed herein are dinucleotide compounds that target telomers in cancer cells and methods for using the dinucleotide compounds to treat cancers alone or before administration of checkpoint inhibitors.

公开(公告)号：US11903935B2

公开(公告)日：2024-02-20

申请号：US17508321

申请日：2021-10-22

Applicant: Washington University ,  Disarm Therapeutics, Inc.

Inventor： Jeffrey Milbrandt ,  Kow Essuman ,  Yo Sasaki ,  Aaron Diantonio ,  Xianrong Mao ,  Rajesh Devraj ,  Raul Eduardo Krauss ,  Robert Owen Hughes

IPC: A61K31/4439 ,  A61K47/55 ,  A61K47/52 ,  A61P25/28 ,  A61K33/243 ,  A61K31/047 ,  A61K31/145 ,  A61K31/198 ,  A61K31/41 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/566 ,  A61K31/7048 ,  A61K31/7084 ,  A61K33/245 ,  A61K33/28 ,  A61K33/30

CPC classification number: A61K31/4439 ,  A61K31/047 ,  A61K31/145 ,  A61K31/198 ,  A61K31/41 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/566 ,  A61K31/7048 ,  A61K31/7084 ,  A61K33/243 ,  A61K33/245 ,  A61K33/28 ,  A61K33/30 ,  A61K47/52 ,  A61K47/55 ,  A61P25/28

Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

公开(公告)号：US20240033307A1

公开(公告)日：2024-02-01

申请号：US18071215

申请日：2022-11-29

Applicant: SYNGEN BIOTECH CO., LTD.

Inventor： Wei-Jen CHEN ,  Tsung-Yin TANG ,  Ming-Chung TSENG ,  Yu-Shan WEI

IPC: A61K35/744 ,  A61K31/7084 ,  A61P21/06

CPC classification number: A61K35/744 ,  A61K31/7084 ,  A61P21/06

Abstract: A method for enhancing sports performance and alleviating sarcopenia with a Streptococcus thermophiles ST7 fermentation product composition is disclosed. The administration of an effective amount of the Streptococcus thermophiles ST7 fermentation product composition to an individual in advance can increase the ATP content of the individual's muscle cells and lower indices related to fatigue and muscle damage, thereby enhancing the individual's sports performance and improving or preventing sarcopenia and its symptoms.