- 专利标题: DUAL FUNCTION PROTEINS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
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申请号: US15768865申请日: 2016-10-28
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公开(公告)号: US20200024318A1公开(公告)日: 2020-01-23
- 发明人: Jun Hwan KIM , Seyoung LIM , Minji SEO , Hyun Ho CHOI , Dohoon KIM , Mi Kyeong JU , Ju-Young PARK , Seul Gi KIM , Sangmyoun LIM , Jong Gyun KIM , Su Youn NAM
- 申请人: YUHAN CORPORATION
- 申请人地址: KR Seoul
- 专利权人: YUHAN CORPORATION
- 当前专利权人: YUHAN CORPORATION
- 当前专利权人地址: KR Seoul
- 优先权: KR10-2015-0150576 20151028
- 国际申请: PCT/KR2016/012300 WO 20161028
- 主分类号: C07K14/50
- IPC分类号: C07K14/50 ; C07K14/605 ; C07K14/575 ; A61P3/04 ; A61P3/06 ; A61P3/10 ; A61P1/16
摘要:
The present invention provides a dual function protein prepared by linking a biologically active protein and an FGF mutant protein to an Fc region of an immunoglobulin, which has improved pharmacological efficacy, in vivo duration and protein stability. A dual function protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition containing the dual function protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis or cardiovascular diseases.
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