公开(公告)号：US20200024318A1

公开(公告)日：2020-01-23

申请号：US15768865

申请日：2016-10-28

Applicant: YUHAN CORPORATION

Inventor： Jun Hwan KIM ,  Seyoung LIM ,  Minji SEO ,  Hyun Ho CHOI ,  Dohoon KIM ,  Mi Kyeong JU ,  Ju-Young PARK ,  Seul Gi KIM ,  Sangmyoun LIM ,  Jong Gyun KIM ,  Su Youn NAM

IPC: C07K14/50 ,  C07K14/605 ,  C07K14/575 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P1/16

Abstract: The present invention provides a dual function protein prepared by linking a biologically active protein and an FGF mutant protein to an Fc region of an immunoglobulin, which has improved pharmacological efficacy, in vivo duration and protein stability. A dual function protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition containing the dual function protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis or cardiovascular diseases.

公开(公告)号：US20220002368A1

公开(公告)日：2022-01-06

申请号：US17478628

申请日：2021-09-17

Applicant: YUHAN CORPORATION

Inventor： Jun Hwan KIM ,  Seyoung LIM ,  Minji SEO ,  Hyun Ho CHOI ,  Dohoon KIM ,  Mi Kyeong JU ,  Ju-Young PARK ,  Seul Gi KIM ,  Sangmyoun LIM ,  Jong Gyun KIM ,  Su Youn NAM

IPC: C07K14/50 ,  C07K14/575 ,  C07K14/605

Abstract: A dual function protein is disclosed. The dual function protein may be prepared by linking a biologically active protein and an FGF mutant protein to an Fc region of an immunoglobulin. The dual function protein has improved pharmacological efficacy, in vivo duration and protein stability. The dual function protein exhibits improved pharmacological efficacy, in vivo duration and protein stability. A pharmaceutical composition containing the dual function protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis or cardiovascular diseases.