Invention Application
- Patent Title: BRIDGED PIPERIDINE DERIVATIVES
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Application No.: US16337348Application Date: 2017-09-28
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Publication No.: US20200031831A1Publication Date: 2020-01-30
- Inventor: Bjoern BARTELS , Roland JAKOB-ROETNE , Anja LIMBERG , Werner NEIDHART , Hasane RATNI , Michael REUTLINGER , Jérôme Charles SARIE , Greta VASTAKAITE
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Priority: EP16191512.9 20160929
- International Application: PCT/EP2017/074575 WO 20170928
- Main IPC: C07D487/04
- IPC: C07D487/04

Abstract:
The present invention relates to a compound of formula (I), wherein R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, lower alkoxy or lower alkoxy substituted by halogen; R may be the same or different, if n=2 or 3; n is 1, 2 or 3; m is 1, 2 or 3; Ar is a five or six membered heteroaryl group, selected from (II), (III), (IV) or (V) wherein R2 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen or lower alkoxy; R3 is hydrogen or halogen; -( ) m - is —(CH2)m— or to pharmaceutically active acid addition salts thereof. The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-in-farct dementia, dementia pugilistica or Down syndrome.
Public/Granted literature
- US10899766B2 Bridged piperidine derivatives Public/Granted day:2021-01-26
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