Provided is an activation device for a printing blanket and a printing method using a printing blanket that enable a surface of an absorber to be constantly kept clean to enable proper activation of a surface of the printing blanket. The activation device for a printing blanket includes a storage tank having a box shape, the absorber mounted on the storage tank, and a liquid stored in the storage tank. The absorber includes layers of absorbing members and absorbs the liquid from an absorber lower part, and an uppermost layer of the absorber is peelable from the absorber.