- 专利标题： GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
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申请号： US16542166申请日： 2019-08-15
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公开(公告)号： US20200048266A1公开(公告)日： 2020-02-13
- 发明人: Elyse BOURQUE , Mario CABRERA-SALAZAR , Cassandra CELATKA , Seng CHENG , Mary A. CROMWELL , Andrew GOOD , Bradford HIRTH , Katherine JANCSICS , John P. LEONARD , Lingyun LI , James LILLIE , Hanlan LIU , Elina MAKINO , John MARSHALL , Paul MASON , Markus METZ , Fazeela MORSHED , Thomas O'SHEA , Ronald SCHEULE , Renato SKERLJ , Bing WANG , Yibin XIANG , Zhong ZHAO
- 申请人： GENZYME CORPORATION
- 主分类号： C07D487/08
- IPC分类号： C07D487/08 ; A61K31/439 ; A61K31/454 ; A61K38/47 ; C07D453/02 ; C07D453/00 ; A61K31/46 ; A61K31/506 ; A61K31/551 ; C07D455/02
摘要：
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
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