![SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS](/docs/US/2020-02-20/US20200055860A1/abs.jpg.600x600.jpg)
- 专利标题： SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
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申请号： US16478071申请日： 2018-01-18
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公开(公告)号： US20200055860A1公开(公告)日： 2020-02-20
- 发明人: Steven W ANDREWS , James F BLAKE , Julia HAAS , Yutong JIANG , Gabrielle R KOLAKOWSKI , David A MORENO , Li REN , Shane M WALLS
- 申请人： Array BioPharma Inc.
- 国际申请： PCT/US2018/014279 WO 20180118
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
![SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS](/abs-image/US/2020/02/20/US20200055860A1/abs.jpg.150x150.jpg)
摘要：
Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
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