公开(公告)号：US20200055860A1

公开(公告)日：2020-02-20

申请号：US16478071

申请日：2018-01-18

申请人： Array BioPharma Inc.

发明人： Steven W ANDREWS ,  James F BLAKE ,  Julia HAAS ,  Yutong JIANG ,  Gabrielle R KOLAKOWSKI ,  David A MORENO ,  Li REN ,  Shane M WALLS

IPC分类号： C07D487/04

摘要： Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.