- 专利标题： CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
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申请号： US16611624申请日： 2018-05-07
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公开(公告)号： US20200062798A1公开(公告)日： 2020-02-27
- 发明人: Wen-Lian WU , Jongwon LIM , Jared N. Cumming , Benjamin Wesley TROTTER , Wonsuk CHANG
- 申请人： Wen-Lian WU , Jongwon LIM , Jared N. CUMMING , Benjamin Wesley TROTTER , Wonsuk CHANG , Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US2018/031380 WO 20180507
- 主分类号： C07H21/00
- IPC分类号： C07H21/00
摘要：
A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
公开/授权文献
- US11466047B2 Cyclic di-nucleotide compounds as sting agonists 公开/授权日：2022-10-11
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