Certain aspects of the present disclosure provide techniques for wake-up resource randomization for discontinuous reception operation. An example method generally includes obtaining configuration information for receiving at least one wake up signal (WUS) during an OFF duration of a discontinuous reception (DRX) mode of the UE; monitoring, during a WUS monitoring occasion occurring during the OFF duration of the DRX mode, the one or more resources for the at least one WUS based on the configuration information; and transitioning to an ON state of the DRX mode when the at least one WUS is detected in the one or more resources during the monitoring; or remaining in an OFF state of the DRX mode when the at least one WUS is not detected in the one or more resources during the monitoring.