Systems, apparatuses, methods, and computer-readable media are provided for device interface management. A device includes a device interface, a virtual machine (VM) includes a device driver, both to facilitate assignment of the device to the VM, access of the device by the VM, or removal of the device from being assigned to the VM. The VM is managed by a hypervisor of a computing platform coupled to the device by a computer bus. The device interface includes logic in support of a device management protocol to place the device interface in an unlocked state, a locked state to prevent changes to be made to the device interface, or an operational state to enable access to device registers of the device by the VM or direct memory access to memory address spaces of the VM, or an error state. Other embodiments may be described and/or claimed.