Invention Application
- Patent Title: ANTISENSE OLIGONUCLEOTIDE CONTROLLING EXPRESSION AMOUNT OF TDP-43 AND USE THEREOF
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Application No.: US16630141Application Date: 2018-07-06
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Publication No.: US20200165610A1Publication Date: 2020-05-28
- Inventor: Yoshitaka NAGAI , Kazuhiro MAETA , Toshihide TAKEUCHI , Masahiro NEYA , Tsuyoshi FUJIHARA , Seiji MATSUDA , Gen SOBUE , Shinsuke ISHIGAKI , Kentaro SAHASHI
- Applicant: OSAKA UNIVERSITY , KNC LABORATORIES CO., LTD. , NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
- Applicant Address: JP Suita JP Kobe JP Nagoya
- Assignee: OSAKA UNIVERSITY,KNC LABORATORIES CO., LTD.,NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
- Current Assignee: OSAKA UNIVERSITY,KNC LABORATORIES CO., LTD.,NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
- Current Assignee Address: JP Suita JP Kobe JP Nagoya
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@2b8b6af5
- International Application: PCT/JP2018/025792 WO 20180706
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/712 ; A61P25/28
Abstract:
The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.
Public/Granted literature
- US11028390B2 Antisense oligonucleotide controlling expression amount of TDP-43 and use thereof Public/Granted day:2021-06-08
Information query
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