REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY

Invention Application

US20200165620A1 REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY 审中-公开

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Patent Title: REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY
Application No.: US16704032

Application Date: 2019-12-05
Publication No.: US20200165620A1

Publication Date: 2020-05-28
Inventor: Roy Curtiss, III , Shifeng Wang , Soo-Young Wanda , Wei Kong
Applicant: The Arizona Board of Regents for and on Behalf of Arizona State University , The Washington University
Main IPC: C12N15/74
IPC: C12N15/74 ; A61K39/00 ; C12N1/36 ; A61K35/74

REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY

Abstract:

The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.

Public/Granted literature

US10774334B2 Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety Public/Granted day:2020-09-15

Information query

Global Dossier Espacenet

IPC分类:

C	化学；冶金
C12	生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程
C12N	微生物或酶；其组合物；繁殖、保藏或维持微生物；变异或遗传工程；培养基（微生物学的试验介质入C12Q1/00）。
C12N15/00	突变或遗传工程；遗传工程涉及的DNA或RNA，载体（如质粒）或其分离、制备或纯化；所使用的宿主（突变体或遗传工程制备的微生物本身入C12N1/00、C12N5/00、C12N7/00；新的植物入A01H；用组织培养技术再生植物入A01H4/00；新的动物入A01K67/00；含有插入活体细胞的遗传物质以治疗遗传疾病的药剂的应用，基因疗法入A61K48/00，一般肽入C07K）
C12N15/09	.DNA重组技术
C12N15/63	..使用载体引入外来遗传物质；载体；其宿主的使用；表达的调节
C12N15/74	...专门适用于大肠杆菌以外之原核细胞宿主（如乳杆菌、小单孢菌）的载体或表达系统