Invention Application
- Patent Title: METHODS AND COMPOSITIONS FOR ENZYME-MEDIATED SITE-SPECIFIC RADIOLABELING OF GLYCOPROTEINS
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Application No.: US16713388Application Date: 2019-12-13
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Publication No.: US20200179541A1Publication Date: 2020-06-11
- Inventor: Brian AGNEW , Robert AGGELER , Hee Chol KANG , Aimei CHEN , Kyle GEE
- Applicant: Life Technologies Corporation
- Main IPC: A61K51/10
- IPC: A61K51/10 ; G01N33/534 ; G01N33/68 ; C07K14/435 ; C07K16/18 ; C12P21/00 ; C12P21/06 ; G01N33/58
Abstract:
Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.
Information query
