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公开(公告)号：US20170333457A1
公开(公告)日：2017-11-23
申请号：US15671360
申请日：2017-08-08
发明人： Brian AGNEW , Upinder SINGH , Scott GRECIAN
IPC分类号： A61K31/655 , A61K31/7008 , C12N7/00
CPC分类号： A61K31/655 , A61K31/7008 , C12N7/00 , C12N2710/14151 , C12N2710/14163 , C12N2740/16051 , C12N2740/16063
摘要： Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.
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公开(公告)号：US20140336079A1
公开(公告)日：2014-11-13
申请号：US14447230
申请日：2014-07-30
发明人： Brian AGNEW , Maura Ford , Kyle Gee , Kapil Kumar
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C07D207/40 , C07D263/32 , C07D295/22 , C07D307/58 , C07D311/88 , C09B11/24 , C12Q1/68 , C12Q1/6841 , C12Q1/686 , G01N33/5308 , G01N33/531 , G01N2333/91245 , Y10T436/143333
摘要： Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling nucleic acids with an azide group.
摘要翻译： 在某些实施方案中提供了形成报道分子，载体分子或固体支持物的叠氮基修饰的核酸缀合物的新方法。 在其它实施方案中提供了用叠氮化物基团酶标记核酸的方法。
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公开(公告)号：US20200216871A1
公开(公告)日：2020-07-09
申请号：US16738274
申请日：2020-01-09
发明人： Brian AGNEW , Kyle GEE , Tamara NYBERG
IPC分类号： C12P21/00 , A61K47/54 , G01N33/531 , C07K1/13 , G01N33/532 , G01N33/50 , G01N33/533 , C07K16/00 , G01N33/58 , C07K14/47
摘要： Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling a biomolecules with an azide group.
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公开(公告)号：US20190177438A1
公开(公告)日：2019-06-13
申请号：US16306610
申请日：2017-06-16
发明人： Brian AGNEW , Robert AGGELER , Rolando BRAWER
摘要： Methods are provided for making bispecific antibodies and antibody conjugates comprising site-specifically cross-linking two or more antibodies, antibody fragments or Fc-fusion proteins. Also provided are compositions and uses for the bispecific antibodies and antibody conjugates. The bispecific antibodies may be used to treat a disease or condition. Also provided are methods for site-specifically conjugating a liposome, an mRNA or an siRNA to an antibody, and uses of the antibody-conjugated liposome, mRNA or siRNA.
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5.发明申请公开(公告)号：US20180078662A1
公开(公告)日：2018-03-22
申请号：US15826593
申请日：2017-11-29
发明人： Brian AGNEW , Robert AGGELER , Hee Chol KANG , Aimei CHEN , Kyle GEE
IPC分类号： A61K51/10 , G01N33/534 , C12P21/00 , C07K16/18 , G01N33/68 , C12P21/06 , C07K14/435 , G01N33/58
CPC分类号： A61K51/10 , C07K14/435 , C07K16/18 , C12P21/005 , C12P21/06 , G01N33/534 , G01N33/582 , G01N33/6854
摘要： Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.
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公开(公告)号：US20170362624A1
公开(公告)日：2017-12-21
申请号：US15474901
申请日：2017-03-30
发明人： Brian AGNEW , Kyle GEE , Tamara NYBERG
IPC分类号： C12P21/00 , A61K47/54 , C07K14/47 , G01N33/50 , G01N33/533 , G01N33/532 , G01N33/531 , G01N33/58 , C07K16/00 , G01N33/534
CPC分类号： C12P21/005 , A61K47/549 , C07K1/13 , C07K14/47 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12Y302/01096 , G01N33/5005 , G01N33/5008 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/581 , G01N33/582 , G01N33/583 , Y10T436/17
摘要： Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling a biomolecules with an azide group.
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公开(公告)号：US20170166943A1
公开(公告)日：2017-06-15
申请号：US15385340
申请日：2016-12-20
发明人： Brian AGNEW , Kyle GEE , Schuyler CORRY
IPC分类号： C12P21/00 , C07K14/47 , G01N33/533 , C07K16/00
摘要： The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.
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公开(公告)号：US20140377837A1
公开(公告)日：2014-12-25
申请号：US14299284
申请日：2014-06-09
发明人： Brian AGNEW , Kyle Gee , Schuyler Corry
IPC分类号： G01N33/58
CPC分类号： C12P21/005 , A61K47/549 , C07K1/13 , C07K14/47 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12Y302/01096 , G01N33/5005 , G01N33/5008 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/581 , G01N33/582 , G01N33/583 , Y10T436/17
摘要： The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.
摘要翻译： 本发明通常涉及在寡糖键上官能化蛋白质，特别是抗体的方法，通过修饰糖基化来人源化抗体的方法，以及与修饰的寡糖连接的新型抗体。 本发明还涉及可用于产生本发明抗体的试剂盒。
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9.发明申请公开(公告)号：US20200179541A1
公开(公告)日：2020-06-11
申请号：US16713388
申请日：2019-12-13
发明人： Brian AGNEW , Robert AGGELER , Hee Chol KANG , Aimei CHEN , Kyle GEE
IPC分类号： A61K51/10 , G01N33/534 , G01N33/68 , C07K14/435 , C07K16/18 , C12P21/00 , C12P21/06 , G01N33/58
摘要： Provided herein are methods, compositions and kits for use in the site-specific labeling of glycoproteins comprising a combination of enzyme-mediated incorporation of modified sugars comprising a chemical handle and cycloaddition chemistry with a labeling molecule comprising a reactive group, a metal ion chelator, and/or a fluorophore.
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公开(公告)号：US20150051096A1
公开(公告)日：2015-02-19
申请号：US14330727
申请日：2014-07-14
发明人： Brian AGNEW , Kyle GEE , Tamara NYBERG
IPC分类号： G01N33/533 , G01N33/58 , G01N33/532 , C12P21/00
CPC分类号： C12P21/005 , A61K47/549 , A61K47/61 , C07K1/13 , C07K14/47 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12Y302/01096 , G01N33/5005 , G01N33/5008 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/581 , G01N33/582 , G01N33/583 , Y10T436/17
摘要： Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling a biomolecules with an azide group.
摘要翻译： 在某些实施方案中提供了形成报道分子，载体分子或固体支持物的叠氮基改性的生物分子缀合物的新方法。 在其它实施方案中提供了用叠氮化物基团对生物分子进行酶标记的方法。
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