- 专利标题： UNIVERSAL SELF-REGULATING MAMMALIAN CELL LINE PLATFORM FOR THE PRODUCTION OF BIOLOGICS
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申请号： US16622509申请日： 2018-06-15
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公开(公告)号： US20200208171A1公开(公告)日： 2020-07-02
- 发明人: Robert YOUNG , Peter Michael O'CALLAGHAN , Thomas PAYNE
- 申请人： LONZA LTD
- 国际申请： PCT/US2018/037792 WO 20180615
- 主分类号： C12N15/85
- IPC分类号： C12N15/85 ; C12N15/11 ; C12N9/22 ; C12P21/00
摘要：
Disclosed are genetic control circuits, cells, and methods that use a repressor polypeptide to reduce the transcription rate of an exogenous therapeutic polypeptide encoding gene in response to a change in condition.
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