- 专利标题: PHARMACEUTICAL COMPOSITION PARTICLES, ORALLY DISINTEGRATING PREPARATION CONTAINING SAME, AND METHOD FOR PRODUCING PHARMACEUTICAL COMPOSITION PARTICLES
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申请号: US16641014申请日: 2018-08-20
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公开(公告)号: US20200214985A1公开(公告)日: 2020-07-09
- 发明人: Tomohiro HAYASHIDA , Yohei HOASHI , Shin IJITSU , Yoshio NAKANO , Junji YAMAZAKI , Katsuhisa INOUE , Atsushi AIZAWA
- 申请人: NIPRO CORPORATION , ZENSEI PHARMACEUTICAL INDUSTRIES CO.,LTD.
- 申请人地址: JP Osaka JP Osaka
- 专利权人: NIPRO CORPORATION,ZENSEI PHARMACEUTICAL INDUSTRIES CO.,LTD.
- 当前专利权人: NIPRO CORPORATION,ZENSEI PHARMACEUTICAL INDUSTRIES CO.,LTD.
- 当前专利权人地址: JP Osaka JP Osaka
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@5a179520
- 国际申请: PCT/JP2018/030618 WO 20180820
- 主分类号: A61K9/28
- IPC分类号: A61K9/28 ; A61K9/48
摘要:
Pharmaceutical composition particle capable of masking an unpalatable taste and improvement in dissolution properties, an orally disintegrating tablet containing the pharmaceutical composition particle, and a method for manufacturing a pharmaceutical composition particle. The pharmaceutical composition particle includes a core particle containing a drug and a water-soluble gelling swelling substance; and an outer layer which contains a water-insoluble substance and constitutes a coating provided on the outer side of the core particle. The method for manufacturing includes: pulverizing a water-soluble gelling swelling substance to have an average particle diameter of 15 μm or less; a core particle manufacturing step of mixing the water-soluble gelling swelling substance pulverized and a drug to manufacture a core particle; and an outer layer formation step of coating the core particle with a water-insoluble substance on the outer side of the core particle.