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1.发明申请公开(公告)号：US20190083628A1
公开(公告)日：2019-03-21
申请号：US16079290
申请日：2017-02-21
发明人： Tomohiro HAYASHIDA , Yohei HOASHI , Shin IJITSU , Yoshio NAKANO , Junji YAMAZAKI , Katsuhisa INOUE , Atsushi AIZAWA
IPC分类号： A61K47/38 , A61K9/20 , A61K47/32 , A61K9/00 , A61K31/136
摘要： Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a core particle containing a water-soluble gelling swelling substance; an intermediate layer containing a drug and coating an outside of the core particle; and an outer layer containing a water-insoluble substance and coating an outside of the intermediate layer. In addition, the orally disintegrating tablet includes the above-described pharmaceutical composition particles.
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公开(公告)号：US20190054029A1
公开(公告)日：2019-02-21
申请号：US16079288
申请日：2017-02-21
发明人： Tomohiro HAYASHIDA , Yohei HOASHI , Shin IJITSU , Yoshio NAKANO , Junji YAMAZAKI , Katsuhisa INOUE , Atsushi AIZAWA
IPC分类号： A61K9/20 , A61K9/00 , A61K31/137 , A61K47/32 , A61K47/38
摘要： Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a drug-containing core particle; an intermediate layer containing a gelling swelling substance and coating an outside of the core particle; and an outermost layer containing a water-insoluble substance and coating an outside of the intermediate layer. In addition, the method for manufacturing the pharmaceutical composition particles includes: a pulverization step of pulverizing the gelling swelling substance so as to have an average particle diameter of 15 μm or less; a suspension step of obtaining a suspension by suspending the gelling swelling substance pulverized at the pulverization step in an organic solvent; an intermediate layer formation step of forming an intermediate layer on an outside of a core particle by spraying the suspension obtained at the suspension step onto the core particle containing a drug; and an outer layer formation step of forming an outer layer by coating an outside of the intermediate layer with a water-insoluble substance.
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公开(公告)号：US20200214985A1
公开(公告)日：2020-07-09
申请号：US16641014
申请日：2018-08-20
发明人： Tomohiro HAYASHIDA , Yohei HOASHI , Shin IJITSU , Yoshio NAKANO , Junji YAMAZAKI , Katsuhisa INOUE , Atsushi AIZAWA
摘要： Pharmaceutical composition particle capable of masking an unpalatable taste and improvement in dissolution properties, an orally disintegrating tablet containing the pharmaceutical composition particle, and a method for manufacturing a pharmaceutical composition particle. The pharmaceutical composition particle includes a core particle containing a drug and a water-soluble gelling swelling substance; and an outer layer which contains a water-insoluble substance and constitutes a coating provided on the outer side of the core particle. The method for manufacturing includes: pulverizing a water-soluble gelling swelling substance to have an average particle diameter of 15 μm or less; a core particle manufacturing step of mixing the water-soluble gelling swelling substance pulverized and a drug to manufacture a core particle; and an outer layer formation step of coating the core particle with a water-insoluble substance on the outer side of the core particle.
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