Systems and methods for distributing power in a power-to-the-edge system architecture are provided. In one embodiment, a system comprises an intelligent power switch configured to couple to a power supply, wherein the intelligent power switch outputs a first differential voltage output; and a plurality of intelligent remote nodes each comprising a management microcontroller (MCU) and a DC-to-DC converter. The intelligent remote nodes each receive the differential voltage output, and are communicatively coupled to a data network. The intelligent power switch comprises a processor executing an intelligent start-up control and switching function and an electrical fault detection function. The intelligent power switch outputs the differential voltage at a first voltage level while the electrical fault detection function monitors the differential voltage output. Based on results of monitoring at the first voltage level, the intelligent power switch switches the output to a second voltage level higher than the first voltage level.