- 专利标题： Cytomegalovirus Vectors Eliciting T Cells Restricted By Major Histocompatibility Complex E Molecules
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申请号： US16696403申请日： 2019-11-26
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公开(公告)号： US20200237915A1公开(公告)日： 2020-07-30
- 发明人: Louis PICKER , Scott Hansen , Klaus Frueh , Daniel Malouli , Jay Nelson , Jonah Sacha , Meaghan Hancock
- 申请人： OREGON HEALTH & SCIENCE UNIVERSITY
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K39/12 ; A61P31/14 ; C12N15/86 ; C12N15/113 ; C07K14/005 ; C12N7/04 ; A61K39/00
摘要：
Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.
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