- 专利标题： CHIMERIC ANTIGEN RECEPTORS (CAR) TO SELECTIVELY TARGET PROTEIN COMPLEXES
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申请号： US16744598申请日： 2020-01-16
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公开(公告)号： US20200247867A1公开(公告)日： 2020-08-06
- 发明人: Laurence J.N. COOPER , Bipulendu JENA
- 申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- 主分类号： C07K14/725
- IPC分类号： C07K14/725 ; C07K16/30 ; C07K16/28 ; C07K14/705 ; C07K16/32
摘要：
Chimeric antigen receptor (CAR) constructs are provided that are able to selectively bind to specific protein complexes, such as HER1/HER3 heterodimer receptors. CAR T-cells comprising these constructs can be used to safely and efficiently target cancer cells expressing specific protein complexes.
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