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公开(公告)号：US20230312675A1
公开(公告)日：2023-10-05
申请号：US18153025
申请日：2023-01-11
IPC分类号： C07K14/725 , C07K14/705 , C07K16/28 , A61K39/00 , C12N5/0783 , A61K39/395 , C07K14/715
CPC分类号： C07K14/7051 , A61K39/0011 , A61K39/001104 , A61K39/001106 , A61K39/001107 , A61K39/001109 , A61K39/00111 , A61K39/001112 , A61K39/001113 , A61K39/001119 , A61K39/001124 , A61K39/001126 , A61K39/001129 , A61K39/001151 , A61K39/001164 , A61K39/001168 , A61K39/00117 , A61K39/001171 , A61K39/001174 , A61K39/001181 , A61K39/001182 , A61K39/00119 , A61K39/001194 , A61K39/39558 , C07K14/70521 , C07K14/7153 , C07K16/2809 , C07K16/2863 , C12N5/0638 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33 , C07K2319/70 , C12N2501/2302 , C12N2501/515
摘要： Chimeric antigen receptors (CARs) and CAR-expressing T cells are provided that can specifically target cells that express an elevated level of a target antigen. Likewise, methods for specifically targeting cells that express elevated levels of antigen (e.g., cancer cells) with CAR T-cell therapies are provided.
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公开(公告)号：US20200247867A1
公开(公告)日：2020-08-06
申请号：US16744598
申请日：2020-01-16
IPC分类号： C07K14/725 , C07K16/30 , C07K16/28 , C07K14/705 , C07K16/32
摘要： Chimeric antigen receptor (CAR) constructs are provided that are able to selectively bind to specific protein complexes, such as HER1/HER3 heterodimer receptors. CAR T-cells comprising these constructs can be used to safely and efficiently target cancer cells expressing specific protein complexes.
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公开(公告)号：US20190055299A1
公开(公告)日：2019-02-21
申请号：US15771128
申请日：2016-10-27
IPC分类号： C07K14/705 , A61P35/00 , A61P35/02 , C07K16/28 , C07K14/725
摘要： Chimeric antigen receptor (CAR) polypeptides are provided comprising an antigen binding domain; a hinge domain; a transmembrane domain and an intracellular signaling domain, wherein the CAR polypeptide binds to a target antigen and wherein the antigen binding domain comprises HCDR sequences from a first antibody that binds to the target antigen and LCDR sequences from a second antibody that binds to the target antigen. In certain aspects, the target antigen is CD123.
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公开(公告)号：US20240156929A1
公开(公告)日：2024-05-16
申请号：US18465547
申请日：2023-09-12
发明人： Laurence J.N. COOPER , Hiroki TORIKAI , Ling ZHANG , Helen HULS , Feng WANG-JOHANNING , Lenka HURTON , Simon OLIVARES , Janani KRISHNAMURTHY
IPC分类号： A61K39/00 , A61K35/17 , A61P37/00 , C07K14/54 , C07K14/705 , C07K14/725 , C07K16/30
CPC分类号： A61K39/0011 , A61K35/17 , A61K39/001104 , A61K39/001106 , A61K39/001109 , A61K39/00111 , A61K39/001112 , A61K39/001113 , A61K39/001119 , A61K39/001124 , A61K39/001129 , A61K39/001151 , A61K39/001164 , A61K39/001168 , A61K39/00117 , A61K39/001171 , A61K39/001174 , A61K39/001181 , A61K39/001182 , A61K39/00119 , A61K39/001194 , A61P37/00 , C07K14/5443 , C07K14/7051 , C07K14/70521 , C07K16/30 , A61K2039/505 , A61K2039/5158 , C07K2317/622 , C07K2319/02 , C07K2319/03 , Y02A50/30
摘要： The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
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公开(公告)号：US20210187028A1
公开(公告)日：2021-06-24
申请号：US17127627
申请日：2020-12-18
IPC分类号： A61K35/17 , A61K39/00 , C12N5/0783
摘要： Provided herein is a method of expanding clinically-relevant quantities of polyclonal γδ T cells that have anti-tumor, anti-viral, and anti-bacterial reactivity. Polyclonal γδ T cells can target a variety of tumors, including solid tumors as well as other conditions, such as viral and bacterial infections.
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公开(公告)号：US20210054346A1
公开(公告)日：2021-02-25
申请号：US17013195
申请日：2020-09-04
IPC分类号： C12N9/06 , C12N9/10 , A61K35/17 , C07K14/54 , C07K14/575 , C07K14/725 , C12N5/0783 , C12N9/48 , G01N33/543
摘要： In some aspects, isolated transgenic cells (e.g., transgenic T cells) are provided that comprise or express a transgene and DHFRFS and/or TYMSSS. Methods for selecting transgeneic cells are also provided.
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公开(公告)号：US20180200299A1
公开(公告)日：2018-07-19
申请号：US15872354
申请日：2018-01-16
IPC分类号： A61K35/17 , C12N5/0783
CPC分类号： A61K35/17 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , C12N5/0636 , C12N5/0638 , C12N2501/2302 , C12N2501/2321 , C12N2501/515 , C12N2502/11 , C12N2502/99
摘要： Provided herein is a method of expanding clinically-relevant quantities of polyclonal γδ T cells that have anti-tumor, anti-viral, and anti-bacterial reactivity. Polyclonal γδ T cells can target a variety of tumors, including solid tumors as well as other conditions, such as viral and bacterial infections.
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公开(公告)号：US20210324071A1
公开(公告)日：2021-10-21
申请号：US17187074
申请日：2021-02-26
发明人： Laurence J.N. COOPER , Ana Beatriz KORNGOLD , Brian A. RABINOVICH , Harjeet SINGH , Simon OLIVARES
IPC分类号： C07K16/28 , C12N15/85 , C07K14/725 , C07K14/705 , C07K14/47 , A61K35/17 , C12N9/12
摘要： Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon.
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公开(公告)号：US20180362648A1
公开(公告)日：2018-12-20
申请号：US15759148
申请日：2016-09-15
IPC分类号： C07K16/28 , C12N5/0783
摘要： Antibodies and antigen binding fragments thereof are provided that bind to T-cell receptors (e.g., TCRα), essentially independent of T-cell epitope specificity. Methods for manipulation of T-cells and methods of treatment using such antibodies are likewise provided.
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公开(公告)号：US20180051265A1
公开(公告)日：2018-02-22
申请号：US15556868
申请日：2016-03-10
摘要： Transposase polypeptides and polynucleotides are provided, which have a high activity in mammalian cells. Methods for engineering cells, such as chimeric antigen T-cells, with the transposes are also provided.
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