- 专利标题: PRECURSOR COMPOUND OF RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND
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申请号: US16852910申请日: 2020-04-20
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公开(公告)号: US20200282082A1公开(公告)日: 2020-09-10
- 发明人: Osamu ITO , Akio HAYASHI , Fumie KUROSAKI , Masahito TOYAMA , Toshiyuki SHINMURA , Arinori HARANO
- 申请人: NIHON MEDI-PHYSICS CO., LTD.
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@7b4e0677
- 主分类号: A61K51/04
- IPC分类号: A61K51/04 ; C07B59/00 ; C07C309/65 ; C07C67/307
摘要:
It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.
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