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    PRECURSOR COMPOUND OF RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND
    2.
    发明申请
    PRECURSOR COMPOUND OF RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND 审中-公开

    公开(公告)号：US20200282082A1

    公开(公告)日：2020-09-10

    申请号：US16852910

    申请日：2020-04-20

    申请人： NIHON MEDI-PHYSICS CO., LTD.

    发明人： Osamu ITO ,  Akio HAYASHI ,  Fumie KUROSAKI ,  Masahito TOYAMA ,  Toshiyuki SHINMURA ,  Arinori HARANO

    IPC分类号： A61K51/04 ,  C07B59/00 ,  C07C309/65 ,  C07C67/307

    摘要： It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.

    PRECURSOR COMPOUND OF RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND
    3.
    发明申请
    PRECURSOR COMPOUND OF RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND 有权

    公开(公告)号：US20210386873A1

    公开(公告)日：2021-12-16

    申请号：US17356757

    申请日：2021-06-24

    申请人： NIHON MEDI-PHYSICS CO., LTD.

    发明人： Osamu ITO ,  Akio HAYASHI ,  Fumie KUROSAKI ,  Masahito TOYAMA ,  Toshiyuki SHINMURA ,  Arinori HARANO

    IPC分类号： A61K51/04 ,  C07B59/00 ,  C07C309/65 ,  C07C67/307

    摘要： It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.

    RADIOACTIVE FLUORINE LABELING PRECURSOR COMPOUND AND METHOD FOR MANUFACTURING RADIOACTIVE FLUORINE LABELED COMPOUND USING THE SAME
    4.
    发明申请
    RADIOACTIVE FLUORINE LABELING PRECURSOR COMPOUND AND METHOD FOR MANUFACTURING RADIOACTIVE FLUORINE LABELED COMPOUND USING THE SAME 审中-公开
    放射性荧光标记前体化合物及使用其制造放射性荧光标记化合物的方法

    公开(公告)号：US20170066748A1

    公开(公告)日：2017-03-09

    申请号：US15254090

    申请日：2016-09-01

    申请人： NIHON MEDI-PHYSICS CO., LTD. ,  TOKYO INSTITUTE OF TECHNOLOGY

    发明人： Masahito TOYAMA ,  Masato KIRIU ,  Hiroshi TANAKA

    IPC分类号： C07D405/06 ,  A61K51/04

    CPC分类号： C07D405/06 ,  A61K51/0453 ,  C07B59/00 ,  C07B2200/05 ,  Y02P20/55

    摘要： There is provided a labeling precursor compound represented by the following general formula (2): wherein R1 represents an alkynyl group, an alkynyloxy group, an azide group, an azidoalkyl group, an arylazide group, a monocyclic or condensed polycyclic aryl group or a nitrogen-containing heterocycle; R2 and R3 each independently represent an alkyl group or a hydroxyalkyl group which hydroxy group may be protected with a protecting group, and n is an integer of 1 or 2; R6 represents an alkyl group or —CONR11R12 wherein R11 and R12 each independently represent an alkyl group or a monocyclic or condensed polycyclic aryl group; and R4, R5, R7 and R8 each independently represent a hydrogen atom, an alkyl group or an alkoxy group.

    摘要翻译： 其中R1表示炔基，炔氧基，叠氮基，叠氮基烷基，芳基叠氮基，单环或缩合多环芳基或含氮杂环; R2和R3各自独立地表示羟基可被保护基保护的烷基或羟烷基，n为1或2的整数; R6表示烷基或-CONR11R12，其中R11和R12各自独立地表示烷基或单环或缩合多环芳基; 并且R 4，R 5，R 7和R 8各自独立地表示氢原子，烷基或烷氧基。

    PRECURSOR COMPOUND OF RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND
    6.
    发明申请
    PRECURSOR COMPOUND OF RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND 有权
    放射性标记有机化合物的前体化合物

    公开(公告)号：US20160082135A1

    公开(公告)日：2016-03-24

    申请号：US14872305

    申请日：2015-10-01

    申请人： NIHON MEDI-PHYSICS CO., LTD.

    发明人： OSAMU ITO ,  Akio HAYASHI ,  Fumie KUROSAKI ,  Masahito TOYAMA ,  Toshiyuki SHINMURA ,  Arinori HARANO

    IPC分类号： A61K51/04

    CPC分类号： A61K51/0402 ,  A61K51/0406 ,  C07B59/00 ,  C07B2200/05 ,  C07C67/307 ,  C07C309/65 ,  C07C2601/04 ,  Y02P20/55

    摘要： It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.

    摘要翻译： 旨在提供一种新的氨基酸有机化合物，其可以用作包括[18 F] FACBC的放射性卤素标记的氨基酸化合物的标记前体化合物，并且其防止甲醇残留在所产生的放射性卤素标记的氨基酸化合物中 由此。 新型氨基酸有机化合物是下式表示的化合物：其中，n为0或1〜4的整数， R1是乙基，1-丙基或异丙​​基取代基; X是卤素取代基或由-OR2表示的基团; R2是具有1至10个碳原子的直链或支链卤代烷基磺酸取代基，具有3至12个碳原子的三烷基甲锡烷基取代基，氟磺酸取代基或芳族磺酸取代基; R3为保护基。