Further lower iron loss can be achieved in a grain-oriented electrical steel sheet including: a predetermined film mainly composed of forsterite on a front and back surfaces thereof; and a plurality of grooves on the front surface thereof, in which the plurality of grooves have an average depth of 6% or more of a thickness of the steel sheet and are spaced a distance of 1 mm to 15 mm from respective adjacent grooves, the steel sheet has a specific magnetic permeability μr15/50 of 35000 or more when subjected to alternating current magnetization at a frequency of 50 Hz and a maximum magnetic flux density of 1.5 T, and the steel sheet includes isolated parts having a presence frequency of 0.3/μm or less, the isolated parts being separated from a continuous part of the film in an interface between the steel sheet and the film in a cross section orthogonal to the rolling direction of the steel sheet.