Disabling communication in a multiprocessor fabric. The multiprocessor fabric may include a plurality of processors and a plurality of communication elements and each of the plurality of communication elements may include a memory. A configuration may be received for the multiprocessor fabric, which specifies disabling of communication paths between one or more of: one or more processors and one or more communication elements; one or more processors and one or more other processors; or one or more communication elements and one or more other communication elements. Accordingly, the multiprocessor fabric may be automatically configured in hardware to disable the communication paths specified by the configuration. The multiprocessor fabric may be operated to execute a software application according to the configuration.