- 专利标题： EXOGENOUS GENE EXPRESSION IN RECOMBINANT ADENOVIRUS FOR MINIMAL IMPACT ON VIRAL KINETICS
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申请号： US16916764申请日： 2020-06-30
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公开(公告)号： US20200325492A1公开(公告)日： 2020-10-15
- 发明人: Clodagh O'Shea , William Partlo , Colin Powers
- 申请人： Salk Institute for Biological Studies
- 申请人地址： US CA La Jolla
- 专利权人： Salk Institute for Biological Studies
- 当前专利权人： Salk Institute for Biological Studies
- 当前专利权人地址： US CA La Jolla
- 主分类号： C12N15/86
- IPC分类号： C12N15/86
摘要：
Recombinant adenovirus genomes that include an exogenous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. Optimal placement of the exogenous genes for minimal impact on viral kinetics is further disclosed. Therapeutic applications of the recombinant adenoviruses are also described.
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