-
公开(公告)号：US11730781B2
公开(公告)日：2023-08-22
申请号：US15945079
申请日：2018-04-04
发明人： Clodagh O'Shea , Colin Powers , Lei Zhang
IPC分类号： A61K35/761 , C12N15/85
CPC分类号： A61K35/761 , C12N15/85 , C12N2710/10322 , C12N2710/10332 , C12N2710/10333 , C12N2710/10341 , C12N2710/10343 , C12N2710/10345 , C12N2810/6018
摘要： Synthetic adenoviruses having chimeric fiber proteins and liver detargeting mutations are described. The synthetic adenovirus vectors are capable of specifically infecting cells at wound sites or in regions of damaged tissue. The synthetic adenovirus vectors also are capable of expressing transgenes, such as wound healing factors, at sites of wounded or damaged tissue. Accordingly, the described vectors can be used to detect wounded or damaged tissue, and/or to promote wound healing and regeneration of damaged tissue, such as by expression of heterologous wound healing or tissue regeneration factors.
-
公开(公告)号：US20200149014A1
公开(公告)日：2020-05-14
申请号：US16749461
申请日：2020-01-22
发明人： Clodagh O'Shea , Colin Powers
IPC分类号： C12N7/00 , C12N15/86 , C12N15/861
摘要： Methods of assembling modified adenoviruses, libraries of adenoviral gene modules and compositions thereof are provided herein.
-
公开(公告)号：US10577589B2
公开(公告)日：2020-03-03
申请号：US14935866
申请日：2015-11-09
发明人： Clodagh O'Shea , Colin Powers
IPC分类号： C12N7/00 , C12N15/861 , C12N15/86
摘要： Methods of assembling modified adenoviruses, libraries of adenoviral gene modules and compositions thereof are provided herein.
-
公开(公告)号：US20180355374A1
公开(公告)日：2018-12-13
申请号：US16109513
申请日：2018-08-22
发明人： Clodagh O'Shea , William Partlo , Colin Powers
IPC分类号： C12N15/85 , C07K14/075 , C12N15/62
CPC分类号： C12N15/85 , C07K14/005 , C07K14/075 , C07K2319/01 , C07K2319/60 , C07K2319/80 , C12N7/00 , C12N15/62 , C12N2015/859 , C12N2320/12 , C12N2320/52 , C12N2710/10331
摘要： Recombinant adenovirus genomes that include a heterologous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. The recombinant adenovirus genomes and recombinant adenoviruses produced by the disclosed genomes can be used, for example, in high-throughput assays to measure virus replication kinetics. Methods for measuring replication kinetics of a recombinant adenovirus are also described.
-
5.发明申请公开(公告)号：US20180221423A1
公开(公告)日：2018-08-09
申请号：US15945079
申请日：2018-04-04
发明人： Clodagh O'Shea , Colin Powers , Lei Zhang
IPC分类号： A61K35/761 , C12N15/85
CPC分类号： A61K35/761 , C12N15/85 , C12N2710/10322 , C12N2710/10332 , C12N2710/10333 , C12N2710/10341 , C12N2710/10343 , C12N2710/10345 , C12N2810/6018
摘要： Synthetic adenoviruses having chimeric fiber proteins and liver detargeting mutations are described. The synthetic adenovirus vectors are capable of specifically infecting cells at wound sites or in regions of damaged tissue. The synthetic adenovirus vectors also are capable of expressing transgenes, such as wound healing factors, at sites of wounded or damaged tissue. Accordingly, the described vectors can be used to detect wounded or damaged tissue, and/or to promote wound healing and regeneration of damaged tissue, such as by expression of heterologous wound healing or tissue regeneration factors.
-
公开(公告)号：US20230088476A1
公开(公告)日：2023-03-23
申请号：US17852891
申请日：2022-06-29
发明人： Clodagh O'Shea , William Partlo , Colin Powers
IPC分类号： C12N15/86
摘要： Recombinant adenovirus genomes that include an exogenous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. Optimal placement of the exogenous genes for minimal impact on viral kinetics is further disclosed. Therapeutic applications of the recombinant adenoviruses are also described.
-
公开(公告)号：US11130968B2
公开(公告)日：2021-09-28
申请号：US16109513
申请日：2018-08-22
发明人： Clodagh O'Shea , William Partlo , Colin Powers
IPC分类号： C12N15/85 , C07K14/075 , C12N15/62 , C07K14/005 , C12N7/00
摘要： Recombinant adenovirus genomes that include a heterologous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. The recombinant adenovirus genomes and recombinant adenoviruses produced by the disclosed genomes can be used, for example, in high-throughput assays to measure virus replication kinetics. Methods for measuring replication kinetics of a recombinant adenovirus are also described.
-
8.发明申请公开(公告)号：US20180355379A1
公开(公告)日：2018-12-13
申请号：US16110207
申请日：2018-08-23
发明人： Clodagh O'Shea , William Partlo , Colin Powers
IPC分类号： C12N15/86
摘要： Recombinant adenovirus genomes that include an exogenous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. Optimal placement of the exogenous genes for minimal impact on viral kinetics is further disclosed. Therapeutic applications of the recombinant adenoviruses are also described.
-
公开(公告)号：US20180100204A1
公开(公告)日：2018-04-12
申请号：US15835892
申请日：2017-12-08
发明人： Clodagh O'Shea , Colin Powers
IPC分类号： C12Q1/6897 , C12N7/00 , G01N33/574 , C12N15/86
CPC分类号： C12Q1/6897 , C12N7/00 , C12N15/86 , C12N2710/10045 , C12N2710/10331 , C12N2710/10343 , C12N2830/008 , C12N2830/85 , G01N33/57415 , G01N33/57492 , G01N2800/7028
摘要： Compositions and methods for detecting a cancer in a subject using a recombinant reporter adenovirus are described. In particular, recombinant adenovirus is used to diagnose a cancer in a patient and further used for screening compounds effective in treating the cancer in said patient.
-
公开(公告)号：US20160053235A1
公开(公告)日：2016-02-25
申请号：US14935866
申请日：2015-11-09
发明人： Clodagh O'Shea , Colin Powers
摘要： Methods of assembling modified adenoviruses, libraries of adenoviral gene modules and compositions thereof are provided herein.
-
-
-
-
-
-
-
-
-
搜索结果
29 条记录 (耗时 0.025 秒)
