A tamper evident bag has front and rear panels connected together along opposite first and second side edge margins and a bottom edge margins that define a bag interior and a first bag opening therebetween. The first and second side edge margins include first and second peripheral side edges. The front and rear panels each have a tear line with a first end and a second end, the first and second ends being adjacent to and spaced apart from the first peripheral side edge. The first and second ends of each tear line being spaced part. The tear lines extend over the front and rear panels but remain spaced from the second side edge margin. Each tear line defines a respective tear out section on the front and rear panels. The tear out sections are joined along the first side edge margin and are configured to be removed to create a second bag opening.