Invention Application
- Patent Title: TREATMENT OF INFECTIONS AND IMMUNE DYSREGULATION IN PATIENTS WITH PRIMARY IMMUNE DEFICIENCIES USING MRNA-CORRECTED AUTOLOGOUS GRANULOCYTES, LYMPHOCYTES AND/OR NATURAL KILLER CELLS
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Application No.: US16968792Application Date: 2019-02-19
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Publication No.: US20210000926A1Publication Date: 2021-01-07
- Inventor: Suk See De Ravin , Harry L. Malech , Ron Meis , Gary A. Dahl
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic , CELLSCRIPT, LLC
- Applicant Address: US MD Bethesda; US WI Madison
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Servic,CELLSCRIPT, LLC
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Servic,CELLSCRIPT, LLC
- Current Assignee Address: US MD Bethesda; US WI Madison
- International Application: PCT/US2019/018606 WO 20190219
- Main IPC: A61K38/44
- IPC: A61K38/44 ; A61K35/17 ; A61K35/15 ; C12N9/02 ; C12N5/0787 ; C12N5/0783 ; A61P31/00 ; A61K35/28 ; A61K45/06
Abstract:
Provided are compositions and methods for treating a subject having a primary immune deficiency (PID), for example who is suffering from a chronic viral, bacterial, or fungal infection, using autologous granulocytes, autologous lymphocytes, and/or NK cells containing exogenous mRNA encoding the missing or defective protein.
Information query
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