![3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS](/docs/US/2021-01-14/US20210009539A1/abs.jpg.600x600.jpg)
- 专利标题： 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
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申请号： US17031814申请日： 2020-09-24
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公开(公告)号： US20210009539A1公开(公告)日： 2021-01-14
- 发明人: Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, JR. , David S. Millan , Matthew W. Martin , Kenneth W. Bair
- 申请人： Valo Early Discovery, Inc.
- 申请人地址： US MA Boston
- 专利权人： Valo Early Discovery, Inc.
- 当前专利权人： Valo Early Discovery, Inc.
- 当前专利权人地址： US MA Boston
- 主分类号： C07D267/14
- IPC分类号： C07D267/14 ; C07D413/06 ; C07D413/12 ; C07D413/04 ; C07D267/12 ; C07D243/14 ; C07D291/08 ; C07D401/06 ; C07D401/10 ; C07D403/06 ; C07D403/10 ; C07D405/06 ; C07D413/14 ; C07D417/04 ; C07D471/04 ; C07D498/04 ; C07D498/08 ; C07D493/08 ; C07D413/08 ; C07D491/107 ; C07D495/10
![3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS](/abs-image/US/2021/01/14/US20210009539A1/abs.jpg.150x150.jpg)
摘要：
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
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