- 专利标题： SYSTEMS METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING
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申请号： US16650480申请日： 2018-10-04
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公开(公告)号： US20210009972A1公开(公告)日： 2021-01-14
- 发明人: Feng Zhang , Jonathan Gootenberg , Omar Abudayyeh
- 申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 申请人地址： US MA Cambridge; US MA Cambridge; US MA Cambridge
- 专利权人： THE BROAD INSTITUTE, INC.,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 当前专利权人： THE BROAD INSTITUTE, INC.,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 当前专利权人地址： US MA Cambridge; US MA Cambridge; US MA Cambridge
- 国际申请： PCT/US18/54469 WO 20181004
- 主分类号： C12N9/22
- IPC分类号： C12N9/22 ; C12N15/113 ; C12N9/78 ; C12N15/86
摘要：
The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
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