发明申请
- 专利标题: STING MODULATOR COMPOUNDS WITH SULFAMATE LINKAGES, AND METHODS OF MAKING AND USING
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申请号: US17040083申请日: 2019-03-22
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公开(公告)号: US20210015915A1公开(公告)日: 2021-01-21
- 发明人: Jeffrey CIAVARRI , Dylan Bradley ENGLAND , Kenneth M. GIGSTAD , Alexandra E. GOULD , Paul GREENSPAN , Yongbo HU , Shi-Chung HUANG , Steven Paul LANGSTON , Hirotake MIZUTANI , Zhan SHI , Stepan VYSKOCIL , He XU
- 申请人: Takeda Pharmaceutical Company Limited
- 申请人地址: JP Osaka
- 专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人地址: JP Osaka
- 国际申请: PCT/IB2019/052364 WO 20190322
- 主分类号: A61K39/39
- IPC分类号: A61K39/39 ; C07H21/04
摘要:
The present disclosure provides novel compounds of Formula (I) below. Compounds of the disclosure act as STING modulators/agonists. The present disclosure further relates to methods of synthesis of compounds of Formula (I) and methods of using of compounds of Formula (I) for the prophylaxis or treatment of cancer and other STING-related diseases. The compounds have the structure represented by Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
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