公开(公告)号：US20210015915A1

公开(公告)日：2021-01-21

申请号：US17040083

申请日：2019-03-22

申请人： Takeda Pharmaceutical Company Limited

发明人： Jeffrey CIAVARRI ,  Dylan Bradley ENGLAND ,  Kenneth M. GIGSTAD ,  Alexandra E. GOULD ,  Paul GREENSPAN ,  Yongbo HU ,  Shi-Chung HUANG ,  Steven Paul LANGSTON ,  Hirotake MIZUTANI ,  Zhan SHI ,  Stepan VYSKOCIL ,  He XU

IPC分类号： A61K39/39 ,  C07H21/04

摘要： The present disclosure provides novel compounds of Formula (I) below. Compounds of the disclosure act as STING modulators/agonists. The present disclosure further relates to methods of synthesis of compounds of Formula (I) and methods of using of compounds of Formula (I) for the prophylaxis or treatment of cancer and other STING-related diseases. The compounds have the structure represented by Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230293522A1

公开(公告)日：2023-09-21

申请号：US18045748

申请日：2022-10-11

申请人： Takeda Pharmaceutical Company Limited

发明人： Matthew O. DUFFEY ,  Dylan ENGLAND ,  Brian Scott FREEZE ,  Zhigen HU ,  Steven LANGSTON ,  Charles MCINTYRE ,  Hirotake MIZUTANI ,  Koji ONO ,  He XU

IPC分类号： A61K31/506 ,  C07D409/14 ,  C07D409/06 ,  C07D405/06 ,  C07D471/04 ,  C07D495/04 ,  C07D487/04 ,  C07D491/052 ,  C07D513/04 ,  C07D498/04 ,  C07D493/04 ,  A61K31/505 ,  A61K31/34 ,  C07F9/535 ,  C07F9/54 ,  C07F9/6558 ,  C07F9/655

CPC分类号： A61K31/506 ,  C07D409/14 ,  C07D409/06 ,  C07D405/06 ,  C07D471/04 ,  C07D495/04 ,  C07D487/04 ,  C07D491/052 ,  C07D513/04 ,  C07D498/04 ,  C07D493/04 ,  A61K31/505 ,  A61K31/34 ,  C07F9/5352 ,  C07F9/5442 ,  C07F9/65586 ,  C07F9/65522

摘要： Disclosed are chemical entities which are compounds of formula (I):




or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra′, Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

公开(公告)号：US20210171565A1

公开(公告)日：2021-06-10

申请号：US16762710

申请日：2018-11-09

申请人： Takeda Pharmaceutical Company Limited

发明人： Stepan VYSKOCIL ,  Jeffrey CIAVARRI ,  Courtney CULLIS ,  Dylan Bradley ENGLAND ,  Alexandra E. GOULD ,  Paul GREENSPAN ,  Yongbo HU ,  Steven LANGSTON ,  Gang LI ,  Hirotake MIZUTANI ,  Masanori OKANIWA

IPC分类号： C07H19/207

摘要： The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases. The present disclosure relates to a compound represented by the Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240209017A1

公开(公告)日：2024-06-27

申请号：US18052083

申请日：2022-11-02

申请人： Takeda Pharmaceutical Company Limited

发明人： Stepan VYSKOCIL ,  Jeffrey CIAVARRI ,  Courtney CULLIS ,  Dylan Bradley ENGLAND ,  Alexandra E. GOULD ,  Paul GREENSPAN ,  Yongbo HU ,  Steven LANGSTON ,  Gang LI ,  Hirotake MIZUTANI ,  Masanori OKANIWA

IPC分类号： C07H19/207

CPC分类号： C07H19/207

摘要： The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.
The present disclosure relates to a compound represented by the Formula (I):






wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.