Invention Application
- Patent Title: METHOD OF GENERATION OF A STATE INDICATOR OF A PERSON IN COMA
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Application No.: US16982174Application Date: 2019-03-22
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Publication No.: US20210022638A1Publication Date: 2021-01-28
- Inventor: David HOLCMAN , Adrien DOUMERGUE , Nathalie KUBIS , Alexandra RICHARD , Aymeric FLOYRAC
- Applicant: PARIS SCIENCES ET LETTRES - QUARTIER LATIN , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ASSISTANCE PUBLIQUE HOPITAUX DE PARIS , ÉCOLE NORMALE SUPÉRIEURE , UNIVERSITÉ DE PARIS , INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
- Applicant Address: FR Paris; FR Paris; FR Paris; FR Paris; FR Paris; FR Paris Cedex 13
- Assignee: PARIS SCIENCES ET LETTRES - QUARTIER LATIN,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,ASSISTANCE PUBLIQUE HOPITAUX DE PARIS,ÉCOLE NORMALE SUPÉRIEURE,UNIVERSITÉ DE PARIS,INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
- Current Assignee: PARIS SCIENCES ET LETTRES - QUARTIER LATIN,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,ASSISTANCE PUBLIQUE HOPITAUX DE PARIS,ÉCOLE NORMALE SUPÉRIEURE,UNIVERSITÉ DE PARIS,INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
- Current Assignee Address: FR Paris; FR Paris; FR Paris; FR Paris; FR Paris; FR Paris Cedex 13
- Priority: FR1852473 20180322
- International Application: PCT/FR2019/050664 WO 20190322
- Main IPC: A61B5/0484
- IPC: A61B5/0484 ; A61B5/04 ; A61B5/00

Abstract:
This method for generating an indicator of the state of a patient in coma includes: generating at least one auditory stimulation by generating a sequence of auditory stimuli, the sequence producing evoked potentials in the patient; acquiring a first electroencephalographic signal produced by patient from at least one electrode; estimating at least one pair of values corresponding to a first parameter and a second parameter extracted from the first acquired signal, including estimating a first pair of values such that calculating the first parameter includes an estimation of the amplitude variance of the first signal within a predefined time window and the calculation of the second parameter includes an estimation of the correlation of two segments of the first signal; generating a state indicator for the or each pair of values of the first and second parameters, the values defining coordinates of a point in a reference base.
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