- 专利标题： HETEROCYCLIC INHIBITORS OF MONOCARBOXYLATE TRANSPORTERS
-
申请号： US16949983申请日： 2020-11-23
-
公开(公告)号： US20210094969A1公开(公告)日： 2021-04-01
- 发明人: Thomas D, Bannister , William R. Roush , John L. Cleveland , Jun Yong Choi , Reji N. Nair , Andy S. Tsai , Jitendra K. Mishra
- 申请人： The Scripps Research Institute
- 申请人地址： US CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： US CA La Jolla
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61K31/519 ; C07D487/04 ; A61K31/155 ; A61K31/5025
摘要：
The invention provides compounds of formulae A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
公开/授权文献
- US11560389B2 Heterocyclic inhibitors of monocarboxylate transporters 公开/授权日：2023-01-24