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公开(公告)号:US10851113B2
公开(公告)日:2020-12-01
申请号:US16439950
申请日:2019-06-13
发明人: Thomas D. Bannister , William R. Roush , Jun Yong Choi , Reji Nair , Andy S. Tsai , Jitendra K. Mishra , John L. Cleveland
IPC分类号: C07D487/04 , C07D495/04 , A61K31/519 , A61K31/155 , A61K31/5025
摘要: The invention provides heterocyclic compounds of formula A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
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公开(公告)号:US20190330228A1
公开(公告)日:2019-10-31
申请号:US16439950
申请日:2019-06-13
发明人: Thomas D. Bannister , William R. Roush , Jun Yong Choi , Reji Nair , Andy S. Tsai , Jitendra K. Mishra , John L. Cleveland
IPC分类号: C07D495/04 , A61K31/519 , C07D487/04 , A61K31/155 , A61K31/5025
摘要: The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
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公开(公告)号:US10329303B2
公开(公告)日:2019-06-25
申请号:US15545168
申请日:2016-01-22
发明人: Thomas D. Bannister , William R. Roush , Jun Yong Choi , Reji Nair , Andy S. Tsai , Jitendra K. Mishra , John L. Cleveland
IPC分类号: A61K31/519 , C07D495/04 , C07D487/04 , A61K31/155 , A61K31/5025
摘要: The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
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公开(公告)号:US20180002343A1
公开(公告)日:2018-01-04
申请号:US15545168
申请日:2016-01-22
发明人: Thomas D. Bannister , William R. Roush , Jun Yong Choi , Reji Nair , Andy S. Tsai , Jitendra K. Mishra , John L. Cleveland
IPC分类号: C07D495/04 , A61K31/519 , A61K31/5025 , C07D487/04 , A61K31/155
CPC分类号: C07D495/04 , A61K31/155 , A61K31/5025 , A61K31/519 , C07D487/04 , A61K2300/00
摘要: The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
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公开(公告)号:US20210094969A1
公开(公告)日:2021-04-01
申请号:US16949983
申请日:2020-11-23
发明人: Thomas D, Bannister , William R. Roush , John L. Cleveland , Jun Yong Choi , Reji N. Nair , Andy S. Tsai , Jitendra K. Mishra
IPC分类号: C07D495/04 , A61K31/519 , C07D487/04 , A61K31/155 , A61K31/5025
摘要: The invention provides compounds of formulae A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
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