Invention Application
- Patent Title: MODIFIED DOUBLE-STRANDED DONOR TEMPLATES
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Application No.: US17079097Application Date: 2020-10-23
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Publication No.: US20210123035A1Publication Date: 2021-04-29
- Inventor: Jessica Woodley , Bernice Thommandru , Joseph Dobosy , Mark Behlke , Adam Clore , Garrett Rettig , Beimeng Sun
- Applicant: INTEGRATED DNA TECHNOLOGIES, INC.
- Applicant Address: US IA Coralville
- Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
- Current Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
- Current Assignee Address: US IA Coralville
- Main IPC: C12N9/22
- IPC: C12N9/22 ; C12N15/113
Abstract:
Described herein are compositions and methods for improving homology directed repair (HDR) efficiency and reducing homology-independent integration following introduction of double strand breaks with engineered nucleases. Additionally, modifications to double stranded DNA donors to improve the donor potency and efficiency of homology directed repair following introduction of double stranded breaks with programmable nucleases.
Public/Granted literature
- US12123033B2 Modified double-stranded donor templates Public/Granted day:2024-10-22
Information query
