- 专利标题： PRODUCTION OF ENGINEERED T-CELLS BY SLEEPING BEAUTY TRANSPOSON COUPLED WITH METHOTREXATE SELECTION
-
申请号： US17096138申请日： 2020-11-12
-
公开(公告)号： US20210139583A1公开(公告)日： 2021-05-13
- 发明人: Michael C. Jensen , Suzie Pun , Nataly Kacherovsky
- 申请人： Seattle Children's Hospital (dba Seattle Children's Research Institute)
- 申请人地址： US WA Seattle
- 专利权人： Seattle Children's Hospital (dba Seattle Children's Research Institute)
- 当前专利权人： Seattle Children's Hospital (dba Seattle Children's Research Institute)
- 当前专利权人地址： US WA Seattle
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K35/17 ; C12N5/0783 ; C07K14/725 ; C07K14/705 ; C12N15/85 ; A61K35/28 ; A61K38/17 ; C07K14/71 ; C07K14/715 ; C07K16/32 ; A61K39/395 ; C12N9/12
摘要：
Aspects of the invention described herein include methods of treating, inhibiting, ameliorating and/or eliminating a virus or cancer cells in a subject utilizing genetically engineered human T-cells having receptors for a molecule presented by the virus or the cancer cells, wherein the genetically engineered T cells are isolated utilizing a two-stage MTX selection that employs increasing concentrations of MTX.
信息查询
