Lock devices, systems, and methods including an internal mechanism to permit backdriven operation and lost motion operation. In one form, the lock includes an assembly of parts with locating features that assist in those parts being assembled with other parts of the assembly in a single, relative orientation. Further, lost motion may be utilized to accommodate manual displacement of one or more components that can also be displaceable, in some embodiments, via operation of a motor. The lock can also include an internal power source capable of driving electronics used to determine handedness of a door.